Synthetic Promoters with Enhanced Cell-State Specificity (SPECS)
Identifying cell-state
specific promoters is crucial for both basic and applied research but
remains challenging. To address this, we developed a high-throughput
synthetic promoter engineering and screening platform capable of
generating compact promoters with enhanced specificity for virtually any
cell state, without the need for prior gene regulation data. This
platform has been successfully applied to discover SPECS for a wide
array of normal and disease cell states.
We develop scalable platforms that perform complex logic operations, paving the way for new therapeutic approaches and biotechnological innovations.
Industry Collaborations
Our lab collaborates with industry partners, including Circuit-Bio, ViVac, MeatoLogic, and Abintus-Bio, to advance synthetic biology solutions for clinical and commercial applications.
